/**
 * CRC Warriors - Clinical Trials Explorer
 * Theme: Teal → Violet → Pink
 * Version: 2.0
 */

/* ===== CSS Variables ===== */
:root {
    --teal: #0d9488;
    --teal-light: #14b8a6;
    --teal-dark: #0f766e;
    --violet: #8b5cf6;
    --violet-light: #a78bfa;
    --violet-dark: #7c3aed;
    --pink: #ec4899;
    --pink-light: #f472b6;
    --amber: #f59e0b;
    --amber-light: #fbbf24;
    --green: #10b981;
    --red: #ef4444;
    --text-dark: #1e293b;
    --text-muted: #64748b;
    --bg-light: #f8fafc;
    --border: #e2e8f0;
    --primary: #3b82f6;
    --primary-dark: #1d4ed8;
}

/* ===== Hero Section ===== */
.hero-section {
    background: linear-gradient(135deg, var(--primary) 0%, var(--primary-dark) 100%);
    padding: 3rem 0;
    color: white;
    position: relative;
    overflow: hidden;
    margin-bottom: 2rem;
}

.hero-section::before {
    content: '';
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    bottom: 0;
    background: radial-gradient(circle at 20% 50%, rgba(255,255,255,0.1) 0%, transparent 50%);
    animation: float 15s ease-in-out infinite;
}

@keyframes float {
    0%, 100% { transform: translate(0, 0); }
    50% { transform: translate(20px, -20px); }
}

.hero-section h1 {
    font-size: 2.5rem;
    font-weight: 800;
    margin-bottom: 0.5rem;
    position: relative;
    z-index: 2;
}

.hero-section h1 i {
    margin-right: 0.5rem;
}

.hero-section .lead {
    font-size: 1.25rem;
    opacity: 0.95;
    position: relative;
    z-index: 2;
}

.hero-section .badge {
    font-size: 0.9rem;
    padding: 0.5rem 1rem;
    border-radius: 50px;
}

.hero-section .btn-light {
    background: white;
    color: var(--text-dark);
    border: none;
    font-weight: 700;
    border-radius: 50px;
    padding: 0.75rem 1.5rem;
    transition: all 0.3s;
}

.hero-section .btn-light:hover {
    transform: translateY(-3px);
    box-shadow: 0 10px 30px rgba(25,135,84,1);
    color: var(--green);
}

.hero-section .btn-outline-light {
    border: 2px solid rgba(255,255,255,0.5);
    border-radius: 50px;
    font-weight: 600;
    padding: 0.75rem 1.5rem;
}

.hero-section .btn-outline-light:hover {
    background: rgba(255,255,255,0.2);
    border-color: white;
}

/* ===== Statistics Container ===== */
.stats-container {
    margin-bottom: 2rem;
}

.stat-card {
    background: white;
    border: 2px solid var(--border);
    border-radius: 20px;
    padding: 1.5rem;
    margin-bottom: 1rem;
    position: relative;
    overflow: hidden;
    transition: all 0.3s ease;
}

.stat-card:hover {
    transform: translateY(-5px);
    box-shadow: 0 15px 40px rgba(139, 92, 246, 0.15);
}

.stat-card.primary {
    border-left: 4px solid var(--violet);
}

.stat-card.primary:hover {
    border-color: var(--violet);
}

.stat-card.success {
    border-left: 4px solid var(--teal);
}

.stat-card.success:hover {
    border-color: var(--teal);
}

.stat-card.info {
    border-left: 4px solid var(--pink);
}

.stat-card.info:hover {
    border-color: var(--pink);
}

.stat-card.warning {
    border-left: 4px solid var(--amber);
}

.stat-card.warning:hover {
    border-color: var(--amber);
}

.stat-number {
    font-size: 2.5rem;
    font-weight: 800;
    background: linear-gradient(135deg, var(--teal), var(--violet));
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
    background-clip: text;
    line-height: 1;
}

.stat-card.success .stat-number {
    background: linear-gradient(135deg, var(--teal), var(--teal-light));
    -webkit-background-clip: text;
    background-clip: text;
}

.stat-card.info .stat-number {
    background: linear-gradient(135deg, var(--pink), var(--pink-light));
    -webkit-background-clip: text;
    background-clip: text;
}

.stat-card.warning .stat-number {
    background: linear-gradient(135deg, var(--amber), var(--amber-light));
    -webkit-background-clip: text;
    background-clip: text;
}

.stat-label {
    font-size: 0.9rem;
    font-weight: 600;
    color: var(--text-muted);
    margin-top: 0.25rem;
}

.stat-card i.position-absolute {
    color: var(--violet);
}

/* ===== Search Section ===== */
.search-section {
    background: white;
    border: 2px solid var(--border);
    border-radius: 24px;
    padding: 2rem;
    margin-bottom: 2rem;
    box-shadow: 0 10px 40px rgba(0,0,0,0.05);
    transition: border-color 0.3s;
}

.search-section:hover {
    border-color: var(--violet);
}

.search-section h3 {
    font-weight: 800;
    color: var(--text-dark);
}

.search-section h3 i {
    color: var(--violet);
}

.search-section .form-control {
    border: 2px solid var(--border);
    border-radius: 50px;
    padding: 1rem 1.5rem 1rem 3rem;
    font-size: 1rem;
    transition: all 0.3s;
}

.search-section .form-control:focus {
    border-color: var(--violet);
    box-shadow: 0 0 0 4px rgba(139, 92, 246, 0.15);
}

.search-section .btn-primary {
    background: #0d6efd;
    border: none;
    border-radius: 50px;
    font-weight: 700;
    padding: 1rem 2rem;
    transition: all 0.3s;
}

.search-section .btn-primary:hover {
    transform: translateY(-3px);
    box-shadow: 0 10px 30px rgba(13, 110, 253, 0.3);
}

/* ===== Quick Filters ===== */
.filter-badge {
    border: 2px solid var(--border);
    border-radius: 50px;
    padding: 0.5rem 1rem;
    font-weight: 600;
    transition: all 0.3s;
    background: white;
    color: var(--text-dark);
}

.filter-badge.btn-outline-primary {
    border-color: var(--violet);
    color: var(--violet);
}

.filter-badge:hover {
    border-color: var(--violet);
    background: linear-gradient(135deg, #f0fdfa, #ede9fe);
    color: var(--violet) !important;
}

.filter-badge.btn-outline-primary:hover {
    background: linear-gradient(135deg, #f0fdfa, #ede9fe);
    border-color: var(--violet);
    color: var(--violet) !important;
}

.filter-badge.active,
.filter-badge:active {
    background: linear-gradient(135deg, var(--violet), var(--pink));
    border-color: var(--violet);
    color: white;
}

.filter-badge[data-filter="medication"] {
    border-color: var(--teal);
}

.filter-badge[data-filter="medication"]:hover {
    background: linear-gradient(135deg, #f0fdfa, #ccfbf1);
    color: var(--teal) !important;
}

/* Tumor-Agnostic (success) hover */
.filter-badge.btn-outline-success:hover {
    background: linear-gradient(135deg, #d1fae5, #a7f3d0);
    border-color: var(--teal);
    color: #065f46 !important;
}

/* New Trials (danger) hover */
.filter-badge.btn-outline-danger:hover {
    background: linear-gradient(135deg, #fee2e2, #fecaca);
    border-color: var(--red);
    color: #991b1b !important;
}

/* Info (medications like Pembrolizumab) hover */
.filter-badge.btn-outline-info:hover {
    background: linear-gradient(135deg, #f0fdfa, #ccfbf1);
    border-color: var(--teal);
    color: var(--teal-dark) !important;
}

.filter-badge .bi-circle-fill.text-success {
    color: var(--teal) !important;
}

/* ===== Advanced Filters Card ===== */
.card {
    border: 2px solid var(--border);
    border-radius: 20px;
    overflow: hidden;
    box-shadow: 0 5px 20px rgba(0,0,0,0.05);
}

.card:hover {
    border-color: var(--violet);
}

.card-header.bg-light {
    background: linear-gradient(135deg, #f0fdfa, #ede9fe) !important;
    border-bottom: 2px solid var(--border);
    padding: 1.25rem 1.5rem;
}

.card-header h4, .card-header h5 {
    font-weight: 800;
    color: var(--text-dark);
}

.card-header h4 i, .card-header h5 i {
    color: var(--violet);
}

.card-body {
    padding: 1.5rem;
}

/* ===== Form Controls ===== */
.form-label {
    font-weight: 700;
    color: var(--text-dark);
    margin-bottom: 0.5rem;
}

.form-select, .form-control {
    border: 2px solid var(--border);
    border-radius: 12px;
    padding: 0.75rem 1rem;
    transition: all 0.3s;
}

.form-select:focus, .form-control:focus {
    border-color: var(--violet);
    box-shadow: 0 0 0 4px rgba(139, 92, 246, 0.15);
}

.form-check-input:checked {
    background-color: var(--violet);
    border-color: var(--violet);
}

.form-check-input:focus {
    box-shadow: 0 0 0 4px rgba(139, 92, 246, 0.15);
}

/* ===== Genetic Filters Card ===== */
.card.border-primary {
    border-color: var(--violet) !important;
}

.card-header.bg-primary {
    background: linear-gradient(135deg, var(--teal), var(--violet)) !important;
    border: none;
}

.card-header.bg-primary h5 {
    color: white;
}

.card-header.bg-primary small {
    color: rgba(255,255,255,0.8);
}

/* ===== Eligibility Filters ===== */
.eligibility-filters-container {
    background: linear-gradient(135deg, #f0fdfa, #ede9fe);
    border: 2px solid var(--border);
    border-radius: 16px;
    overflow: hidden;
    margin-bottom: 1.5rem;
}

.eligibility-header {
    background: linear-gradient(135deg, var(--teal), var(--violet));
    color: white;
    padding: 1rem 1.5rem;
}

.eligibility-header h5 {
    font-weight: 700;
    margin: 0;
}

.eligibility-header small {
    opacity: 0.9;
}

.eligibility-body {
    padding: 1.5rem;
    background: white;
}

.filter-section {
    background: #f8fafc;
    border: 2px solid var(--border);
    border-radius: 12px;
    padding: 1rem;
    height: 100%;
}

.filter-section h6 {
    font-weight: 700;
    color: var(--text-dark);
    margin-bottom: 1rem;
}

.filter-section h6 i {
    color: var(--violet);
}

.filter-checkbox-group {
    display: flex;
    flex-direction: column;
    gap: 0.5rem;
}

.age-range-badge {
    background: linear-gradient(135deg, #f0fdfa, #ede9fe);
    color: var(--violet);
    font-size: 0.75rem;
    padding: 0.2rem 0.5rem;
    border-radius: 20px;
    margin-left: 0.5rem;
}

/* ===== MSI and Tumor Agnostic Filters ===== */
.msi-filter-container,
.tumor-agnostic-filter-container {
    background: white;
    border: 2px solid var(--border);
    border-radius: 16px;
    padding: 1.5rem;
    transition: border-color 0.3s;
}

.msi-filter-container:hover,
.tumor-agnostic-filter-container:hover {
    border-color: var(--violet);
}

.tumor-agnostic-checkbox {
    background: linear-gradient(135deg, #f0fdfa, #ede9fe);
    border-radius: 10px;
    padding: 0.75rem 1rem;
    display: flex;
    align-items: center;
    gap: 0.5rem;
}

/* ===== Action Buttons ===== */
.btn-match-profile {
    background: #0d6efd;
    border: none;
    color: white;
    font-weight: 700;
    border-radius: 50px;
    padding: 0.75rem 1.5rem;
    transition: all 0.3s;
}

.btn-match-profile:hover {
    transform: translateY(-3px);
    box-shadow: 0 10px 30px rgba(13, 110, 253, 0.35);
    color: white;
}

.btn-match-profile:disabled {
    background: #9ca3af;
}

#applyFilters {
    background: #0d6efd;
    border: none;
    border-radius: 50px;
    font-weight: 700;
    padding: 0.75rem 2rem;
    transition: all 0.3s;
}

#applyFilters:hover {
    transform: translateY(-3px);
    box-shadow: 0 10px 30px rgba(13, 110, 253, 0.35);
}

#clearFilters {
    border: 2px solid var(--border);
    border-radius: 50px;
    font-weight: 600;
    transition: all 0.3s;
}

#clearFilters:hover {
    border-color: var(--red);
    color: var(--red);
}

/* ===== Quick Add Mutations ===== */
.quick-add-mutation {
    border: 2px solid var(--border);
    border-radius: 50px;
    font-weight: 600;
    transition: all 0.3s;
}

.quick-add-mutation:hover {
    background: linear-gradient(135deg, var(--teal), var(--violet));
    border-color: var(--violet);
    color: white;
}

/* ===== Active Filters Indicator ===== */
#activeFiltersIndicator {
    background: linear-gradient(135deg, #f0fdfa, #ede9fe);
    border: 2px solid var(--border);
    border-radius: 12px;
    padding: 1rem;
}

#activeFiltersTags .badge {
    background: linear-gradient(135deg, var(--violet), var(--pink));
    font-weight: 600;
    padding: 0.5rem 1rem;
    border-radius: 50px;
    font-size: 0.85rem;
}

/* ===== Quick Stats Bar ===== */
.quick-stats-bar {
    background: linear-gradient(135deg, var(--teal), var(--violet));
    border-radius: 16px;
    padding: 1.5rem;
    display: flex;
    justify-content: space-around;
    flex-wrap: wrap;
    gap: 1rem;
    margin-bottom: 1.5rem;
}

.quick-stat {
    text-align: center;
    color: white;
}

.quick-stat-value {
    font-size: 2rem;
    font-weight: 800;
}

.quick-stat-label {
    font-size: 0.85rem;
    opacity: 0.9;
}

/* ===== Results Controls ===== */
.results-controls {
    background: white;
    border: 2px solid var(--border);
    border-radius: 16px;
    padding: 1rem 1.5rem;
    margin-bottom: 1.5rem;
    display: flex;
    justify-content: space-between;
    align-items: center;
    flex-wrap: wrap;
    gap: 1rem;
}

.sort-controls {
    display: flex;
    align-items: center;
    gap: 0.5rem;
    flex-wrap: wrap;
}

.sort-controls label {
    font-weight: 700;
    color: var(--text-muted);
}

.sort-btn {
    padding: 0.5rem 1rem;
    border: 2px solid var(--border);
    background: white;
    border-radius: 50px;
    font-size: 0.85rem;
    font-weight: 600;
    cursor: pointer;
    transition: all 0.3s;
    display: flex;
    align-items: center;
    gap: 0.3rem;
}

.sort-btn:hover {
    border-color: var(--violet);
    background: linear-gradient(135deg, #f0fdfa, #ede9fe);
}

.sort-btn.active {
    background: linear-gradient(135deg, var(--violet), var(--pink));
    color: white;
    border-color: var(--violet);
}

.view-btn {
    padding: 0.5rem 0.75rem;
    border: 2px solid var(--border);
    background: white;
    border-radius: 10px;
    cursor: pointer;
    transition: all 0.3s;
}

.view-btn:hover {
    border-color: var(--violet);
}

.view-btn.active {
    background: linear-gradient(135deg, var(--teal), var(--violet));
    color: white;
    border-color: var(--teal);
}

/* ===== Trial Cards ===== */
.trial-card {
    background: white;
    border: 2px solid var(--border);
    border-radius: 20px;
    padding: 1.5rem;
    margin-bottom: 1rem;
    transition: all 0.3s ease;
    position: relative;
}

.trial-card:hover {
    border-color: var(--violet);
    transform: translateY(-5px);
    box-shadow: 0 15px 40px rgba(139, 92, 246, 0.15);
}

.trial-card h5 {
    font-weight: 700;
    color: var(--text-dark);
    margin-bottom: 0.75rem;
}

.trial-card h5 a {
    color: var(--text-dark);
    text-decoration: none;
    transition: color 0.3s;
}

.trial-card h5 a:hover {
    color: var(--violet);
}

.trial-meta {
    display: flex;
    flex-wrap: wrap;
    gap: 1rem;
    margin-bottom: 1rem;
}

.trial-meta span {
    display: flex;
    align-items: center;
    gap: 0.3rem;
    font-size: 0.9rem;
    color: var(--text-muted);
}

.trial-meta i {
    color: var(--violet);
}

.trial-status {
    display: inline-block;
    padding: 0.35rem 0.75rem;
    border-radius: 50px;
    font-size: 0.85rem;
    font-weight: 600;
}

.trial-status.recruiting {
    background: linear-gradient(135deg, #d1fae5, #a7f3d0);
    color: #065f46;
}

.trial-status.active {
    background: linear-gradient(135deg, #fef3c7, #fde68a);
    color: #92400e;
}

.trial-status.completed {
    background: linear-gradient(135deg, #e0e7ff, #c7d2fe);
    color: #3730a3;
}

.trial-status.not-recruiting {
    background: #f1f5f9;
    color: var(--text-muted);
}

/* ===== Match Score Badge ===== */
.match-score-badge {
    position: absolute;
    top: 1rem;
    right: 1rem;
    padding: 0.5rem 1rem;
    border-radius: 50px;
    font-weight: 700;
    font-size: 0.85rem;
}

.match-score-badge.high {
    background: linear-gradient(135deg, var(--teal), var(--teal-light));
    color: white;
}

.match-score-badge.medium {
    background: linear-gradient(135deg, var(--amber), var(--amber-light));
    color: #78350f;
}

.match-score-badge.low {
    background: #f1f5f9;
    color: var(--text-muted);
}

/* ===== Compact View ===== */
.results-compact .trial-card {
    padding: 1rem;
    border-radius: 12px;
}

.results-compact .trial-card h5 {
    font-size: 0.95rem;
    margin-bottom: 0.25rem;
}

.results-compact .trial-meta {
    font-size: 0.8rem;
}

/* ===== Trial Actions ===== */
.trial-actions {
    display: flex;
    gap: 0.5rem;
    flex-wrap: wrap;
    margin-top: 1rem;
}

.trial-actions .btn {
    border-radius: 50px;
    font-weight: 600;
    font-size: 0.85rem;
    padding: 0.5rem 1rem;
}

.trial-actions .btn-outline-primary {
    border: 2px solid var(--violet);
    color: var(--violet);
}

.trial-actions .btn-outline-primary:hover {
    background: linear-gradient(135deg, var(--violet), var(--pink));
    border-color: var(--violet);
    color: white;
}

.trial-actions .btn-outline-success {
    border: 2px solid var(--teal);
    color: var(--teal);
}

.trial-actions .btn-outline-success:hover {
    background: linear-gradient(135deg, var(--teal), var(--teal-light));
    border-color: var(--teal);
    color: white;
}

/* ===== Pagination ===== */
.pagination {
    gap: 0.25rem;
}

.page-link {
    border: 2px solid var(--border);
    border-radius: 10px;
    color: var(--text-dark);
    font-weight: 600;
    padding: 0.5rem 1rem;
    transition: all 0.3s;
}

.page-link:hover {
    border-color: var(--violet);
    background: linear-gradient(135deg, #f0fdfa, #ede9fe);
    color: var(--violet);
}

.page-item.active .page-link {
    background: linear-gradient(135deg, var(--violet), var(--pink));
    border-color: var(--violet);
    color: white;
}

.page-item.disabled .page-link {
    background: #f8fafc;
    color: var(--text-muted);
}

/* ===== Modal ===== */
.modal-content {
    border: none;
    border-radius: 24px;
    overflow: hidden;
}

.modal-header.bg-primary {
    background: linear-gradient(135deg, var(--teal), var(--violet)) !important;
    border: none;
    padding: 1.5rem;
}

.modal-header .modal-title {
    font-weight: 800;
}

.modal-body {
    padding: 2rem;
}

.modal-footer {
    border-top: 2px solid var(--border);
    padding: 1.25rem 1.5rem;
    gap: 0.5rem;
}

.modal-footer .btn {
    border-radius: 50px;
    font-weight: 600;
}

/* ===== Loading Overlay ===== */
.loading-overlay {
    position: fixed;
    top: 0;
    left: 0;
    right: 0;
    bottom: 0;
    background: rgba(255,255,255,0.95);
    display: none;
    justify-content: center;
    align-items: center;
    z-index: 9999;
}

.loading-overlay.show {
    display: flex;
}

.loading-overlay .spinner-border {
    color: var(--violet) !important;
}

/* ===== Alerts ===== */
.alert-info {
    background: linear-gradient(135deg, #f0fdfa, #ede9fe);
    border: 2px solid var(--violet);
    border-radius: 16px;
    color: var(--text-dark);
}

.alert-info i {
    color: var(--violet);
}

#activeFiltersBanner {
    background: linear-gradient(135deg, #f0fdfa, #ede9fe);
    border: 2px solid var(--violet);
    border-radius: 16px;
}

#activeFiltersBanner .badge {
    background: linear-gradient(135deg, var(--violet), var(--pink));
}

/* ===== Medication Filter ===== */
.medication-sync-status.synced {
    color: var(--teal);
}

.medication-sync-status.syncing {
    color: var(--amber);
}

.medication-sync-status.error {
    color: var(--red);
}

.medication-filter-info {
    background: linear-gradient(135deg, #f0fdfa, #ede9fe);
    border-left: 4px solid var(--teal);
    border-radius: 0 12px 12px 0;
    padding: 0.75rem 1rem;
    margin-bottom: 1rem;
}

.medication-filter-info a {
    color: var(--violet);
    font-weight: 600;
}

/* ===== Table ===== */
.table {
    border-radius: 12px;
    overflow: hidden;
}

.table thead th {
    background: #0d9488;
    color: white;
    font-weight: 700;
    border: none;
    padding: 1rem;
}

.table tbody td {
    padding: 0.75rem 1rem;
    border-color: var(--border);
    vertical-align: middle;
}

.table tbody tr:hover {
    background: linear-gradient(135deg, #f0fdfa, #ede9fe);
}

/* ===== Badges ===== */
.badge.bg-danger {
    background: linear-gradient(135deg, var(--red), #f87171) !important;
}

.badge.bg-info {
    background: linear-gradient(135deg, var(--teal), var(--teal-light)) !important;
}

.badge.bg-primary {
    background: linear-gradient(135deg, var(--violet), var(--pink)) !important;
}

.badge.bg-success {
    background: linear-gradient(135deg, var(--teal), var(--green)) !important;
}

/* ===== New Trial Indicator ===== */
.new-trial-badge {
    background: linear-gradient(135deg, var(--pink), var(--pink-light));
    color: white;
    font-size: 0.75rem;
    padding: 0.25rem 0.5rem;
    border-radius: 50px;
    font-weight: 700;
    animation: pulse 2s infinite;
}

@keyframes pulse {
    0%, 100% { opacity: 1; }
    50% { opacity: 0.7; }
}

/* ===== Responsive ===== */
@media (max-width: 768px) {
    .hero-section {
        padding: 2rem 0;
    }
    
    .hero-section h1 {
        font-size: 1.75rem;
    }
    
    .stat-number {
        font-size: 2rem;
    }
    
    .search-section {
        padding: 1.5rem;
    }
    
    .results-controls {
        flex-direction: column;
        align-items: stretch;
    }
    
    .sort-controls {
        justify-content: center;
    }
    
    .quick-stats-bar {
        flex-direction: column;
    }
    
    .trial-card {
        padding: 1.25rem;
    }
    
    .match-score-badge {
        position: static;
        display: inline-block;
        margin-bottom: 0.75rem;
    }
    
    /* ===== Genetic Alterations Table - Mobile Responsive ===== */
    #alterationsTable {
        display: block;
    }
    
    #alterationsTable thead {
        display: none;
    }
    
    #alterationsTable tbody {
        display: block;
    }
    
    #alterationsTable tbody tr {
        display: block;
        background: white;
        border: 2px solid var(--border);
        border-radius: 12px;
        margin-bottom: 1rem;
        padding: 1rem;
        position: relative;
    }
    
    #alterationsTable tbody tr:hover {
        border-color: var(--teal);
    }
    
    #alterationsTable tbody td {
        display: block;
        padding: 0.5rem 0;
        border: none;
        text-align: left;
    }
    
    #alterationsTable tbody td:before {
        content: attr(data-label);
        display: block;
        font-weight: 700;
        font-size: 0.75rem;
        color: var(--teal);
        text-transform: uppercase;
        margin-bottom: 0.25rem;
    }
    
    #alterationsTable tbody td select {
        width: 100%;
    }
    
    /* Actions cell - horizontal layout */
    #alterationsTable tbody td:last-child {
        display: flex;
        gap: 0.5rem;
        flex-wrap: wrap;
        padding-top: 1rem;
        margin-top: 0.5rem;
        border-top: 1px solid var(--border);
    }
    
    #alterationsTable tbody td:last-child:before {
        display: none;
    }
    
    #alterationsTable tbody td:last-child .btn {
        flex: 1;
        min-width: 80px;
    }
    
    /* Card header */
    .card-header.bg-primary {
        padding: 1rem;
    }
    
    .card-header.bg-primary h5 {
        font-size: 1rem;
    }
    
    .card-header.bg-primary small {
        font-size: 0.75rem;
    }
    
    /* Alert info box */
    .card-body .alert-info {
        font-size: 0.85rem;
        padding: 0.75rem;
    }
    
    .card-body .alert-info br {
        display: none;
    }
    
    /* Quick add buttons */
    .quick-add-mutation {
        font-size: 0.8rem;
        padding: 0.4rem 0.8rem;
    }
}

/* ===== NEW Badge ===== */
.new-badge {
    display: inline-block;
    background: linear-gradient(135deg, #ef4444, #f87171);
    color: white;
    padding: 0.2rem 0.6rem;
    border-radius: 50px;
    font-size: 0.65rem;
    font-weight: 700;
    text-transform: uppercase;
    letter-spacing: 0.5px;
    margin-left: 0.5rem;
    vertical-align: middle;
    box-shadow: 0 2px 8px rgba(239, 68, 68, 0.35);
    animation: pulse-new 2s infinite;
}

@keyframes pulse-new {
    0%, 100% { transform: scale(1); }
    50% { transform: scale(1.05); }
}

/* ===== Print Styles ===== */
@media print {
    .hero-section,
    .search-section,
    .card,
    .results-controls,
    .pagination,
    .trial-actions,
    #quickStats {
        display: none !important;
    }
    
    .trial-card {
        break-inside: avoid;
        border: 1px solid #ccc;
        box-shadow: none;
    }
}

/* ===== Phase Badge ===== */
.phase-badge {
    background: linear-gradient(135deg, #8b5cf6, #7c3aed) !important;
    color: white !important;
    font-weight: 600;
    padding: 0.35rem 0.75rem;
    border: none;
}

/* ===== Medication Badge ===== */
.medication-badge {
    background: linear-gradient(135deg, #0ea5e9, #0284c7) !important;
    color: white !important;
    font-weight: 500;
    padding: 0.3rem 0.6rem;
    border: none;
}

/* ===== Status Badges ===== */
.status-badge-success {
    background: linear-gradient(135deg, #10b981, #059669) !important;
    color: white !important;
}
.status-badge-warning {
    background: linear-gradient(135deg, #f59e0b, #d97706) !important;
    color: white !important;
}
.status-badge-danger {
    background: linear-gradient(135deg, #ef4444, #dc2626) !important;
    color: white !important;
}
.status-badge-primary {
    background: linear-gradient(135deg, #3b82f6, #2563eb) !important;
    color: white !important;
}
.status-badge-secondary {
    background: linear-gradient(135deg, #6b7280, #4b5563) !important;
    color: white !important;
}
.status-badge-info {
    background: linear-gradient(135deg, #06b6d4, #0891b2) !important;
    color: white !important;
}